Table 3.
Odds ratios (OR) for endometrial cancer and 95% confidence intervals (CI)
| Marker | rs2234670 | rs2234693 | rs9340799 | rs4986934 | rs1801132 | |||
| Genotype | 00a | Case/controls | 232/441 | 211/382 | 324/573 | 617/1276 | 406/834 | |
| OR (CI) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||
| 01a | Case/controls | 307/618 | 336/670 | 280/632 | 44/89 | 226/468 | ||
| OR (CI) | Univariateb | 0.95 (0.75–1.19) | 0.88 (0.70–1.11) | 0.79 (0.64–0.98) | 1.02 (0.68–1.54) | 1.02 (0.82–1.26) | ||
| Multivariatec | 0.92 (0.72–1.16) | 0.86 (0.68–1.10) | 0.75 (0.60–0.93) | 1.03 (0.67–1.58) | 1.00 (0.80–1.26) | |||
| 11a | Case/controls | 123/309 | 115/316 | 58/163 | 1/3 | 30/66 | ||
| OR (CI) | Univariateb | 0.72 (0.54–0.97) | 0.65 (0.48–0.87) | 0.59 (0.41–0.85) | 0.94 (0.09–9.40) | 0.94 (0.58–1.51) | ||
| Multivariatec | 0.73 (0.54–0.99) | 0.65 (0.48–0.89) | 0.53 (0.37–0.77) | 1.02 (0.09–11.61) | 0.95 (0.58–1.57) |
Univariate results include individuals with complete information about the covariates used in the multivariate analysis.
a The genotypes are rs2234670: 00 = ≤ 14/≤ 14, 01 = ≤ 14/> 14, 11 => 14/> 14; rs2234693: 00 = T/T, 01 = T/C, 11 = C/C; rs9340799: 00 = A/A, 01 = A/G, 11 = G/G; rs4986934: 00 = C/C, 01 = C/T, 11 = T/T; rs1801132: 00 = C/C, 01 = C/G, 11 = G/G. b Long-term users of menopausal hormones and diabetics were over-sampled, thus logistic regression models are conditioned for age- and sampling category, which means that only those with complete information about hormone use and diabetes mellitus were included. c Multivariate models are adjusted for parity (continuous), BMI (continuous), smoking (ever, never) and use of oral contraceptives (ever, never)