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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: Nature. 2008 May 25;453(7198):1112–1116. doi: 10.1038/nature06973

Figure 3. Synergistic response of downstream genes to oncogenic mutations is a strong predictor for critical role in malignant transformation.

Figure 3

(A) Bar graphs indicating percent change in endpoint tumor volume following CRG and non-CRG perturbations in mp53/Ras cells (left and right panel, respectively). Perturbations significantly decreasing tumor size, as compared to matched controls are shown in red (***, p<0.001; **, p<0.01; *, p<0.05; Wilcoxn signed-rank and t-test). (B) Distribution of gene perturbations over the set of genes differentially expressed in mp53/Ras cells, rank-ordered by synergy score. Bars, color-coded as above, indicate perturbed genes. CRG cut-off synergy score (0.9) is indicated by horizontal line.