Interaction of lipocalins with complement C5. A) Binding of human C5 to immobilized TSGP2 and TSGP3. The fit to a two-state conformational change model is shown by the dashed line. Curves from bottom to top, indicate 8, 16, 33, 66, 132, 263, 526 nM, respectively. B) Binding of human C5 to immobilized TSGP2 (channel 2: 219 RU final immobilized level) or moubatin (channel 4: 253 RU final immobilized level). C) C5 (300 nM) injected for different time periods over an immobilized TSGP2 surface.