Table 3.
Unadjusted and adjusted odds ratios (OR) and 95% confidence intervals (CI) for the presence of the p53 signature by various ovarian cancer risk factors, among BRCA+ women.
| Risk Factor | Unadjusted Odds Ratio (95% CI) | Unadjusted p-trend | Adjusted* Odds Ratio (95% CI) | Adjusted* p-trend (if applicable) |
|---|---|---|---|---|
| BRCA mutation: 1 | 1.0 | 1.0 | ||
| 2 | 1.9 (0.7–5.0) | - | 1.8 (0.6–5.3) | - |
| Chemotherapy: Never | 1.0 | 1.0 | ||
| Ever | 1.0 (0.4–2.7) | - | 0.7 (0.2–2.0) | - |
| Personal history of breast cancer: No | 1.0 | 1.0 | ||
| Yes | 0.7 (0.3–1.7) | - | 0.5 (0.2–1.4) | - |
| Menopause type: Surgery | 1.0 | 1.0 | ||
| Chemotherapy | 0.5 (0.1–2.1) | - | 0.7 (0.1–3.4) | - |
| Smoking history: Never | 1.0 | 1.0 | ||
| Ever | 0.8 (0.2–3.4) | - | 0.8 (0.2–3.8) | - |
| Tamoxifen use: Never | 1.0 | 1.0 | ||
| Ever | 0.8 (0.2–3.4) | - | 0.6 (0.1–2.8) | - |
| Age of first childbirth: < 30 yr | 1.0 | 1.0 | ||
| ≥ 30 yr | 3.8 (1.2–12) | 0.04 | 3.5 (0.9–12.9) | 0.15 |
| Age at oophorectomy: ≤ 45 yr | 1.0 | 1.0 | ||
| > 45–55 yr | 0.8 (0.3–2.1) | 0.5 (0.1–2.6) | ||
| > 55 yr | 0.6 (0.2–2.1) | 0.53 | 0.3 (0.01–3.2) | 0.69 |
| Age at menopause: < 50 yr | 1.0 | 1.0 | ||
| ≥ 50 yr | 1.3 (0.5–3.6) | 0.98 | 4.8 (0.9–24.0) | 0.49 |
| Body mass index: < 25 kg/m2 | 1.0 | 1.0 | ||
| 25 – <30 kg/m2 | 0.7 (0.2–2.2) | 0.8 (0.2–2.9) | ||
| ≥ 30 kg/m2 | 0.3 (0.1–1.4) | 0.13 | 0.3 (0.1–1.3) | 0.06 |
| Age at Menarche: ≤ 12 yr | 1.0 | 1.0 | ||
| > 12 yr | 1.0 (0.3–3.2) | 0.71 | 1.7 (0.4–6.3) | 0.65 |
| Oral Contraceptive Use: Never | 1.0 | 1.0 | ||
| Ever | 0.8 (0.3–2.4) | 0.38 | 0.9 (0.3–2.8) | 0.65 |
| Parity: Nulliparous | 1.0 | 1.0 | ||
| 1–2 children | 0.7 (0.2–2.2) | 0.7 (0.2–2.3) | ||
| 3+ children | 0.2 (0.04–0.9) | 0.01 | 0.2 (0.04–0.9) | 0.02 |
*
Adjusted for age and parity as continuous variables.