cIAP2 staining was not detected in untreated hamster pouch tissue specimen (a, ABC stain ×100). Cytoplasmic staining of cIAP2 proteins was detected in the whole epithelial layer (except the basal layer) of a representative 3-week 7,12-dimethylbenz[a]anthracene (DMBA)-treated pouch tissue sample (b, ABC stain ×200). Patchy cytoplasmic staining was detected in the whole layer of a representative specimen of 7-week DMBA-treated pouch tissue (c, ABC stain ×100). Cytoplasmic cIAP2 staining was shown in a representative specimen of hamster pouch tissue treated with DMBA for 14 weeks (d, ABC stain ×100). A similar staining pattern is also observed for survivin immunostaining.