Figure 8.

Hypothesis of the genetic and epigenetic regulation of inhibitors of apoptosis (IAP) family members for 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis (brown line: interactions amongst the IAP family members remain unclear; purple double-head horizontal arrow: exact interrelationship between mutant p53 mechanism and epigenetic alteration is still uncertain; grey single-head vertical arrow: induction; orange single-head vertical arrow: overexpression of IAP members; brown asterisk: possibly partially regulated by epigenetic changes).