Table 3.
Scores for immunohistochemical expression of the five members of the inhibitors of apoptosis family and p53 proteins for 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal-pouch squamous-cell carcinogenesis
| cIAP1 | cIAP2 | NAIP | XIAP | Survivin | p53 | |
|---|---|---|---|---|---|---|
| Untreated | 1 | 0 | 1 | 1 | 0 | 0 |
| Mineral oil-treated | 1 | 0 | 1 | 1 | 0 | 0 |
| 3-week DMBA-treated | *2 | *4 | *3 | *4 | *3 | *3 |
| 7-week DMBA-treated | *4 | *4 | *3 | *4 | *4 | *3 |
| 14-week DMBA-treated | *4 | *4 | *3 | *5 | *4 | *4 |
Staining scores: 0, <10%; 1, 10–25%; 2, 25–50%; 3, 50–75%; 4, 75–90%; 5, 90–100%.
*
Statistical significance as compared with untreated or mineral oil-treated tissues (P < 0.0001, chi-square test).
cIAP1, cellular inhibitors of apoptosis protein 1; cIAP2, cellular inhibitors of apoptosis protein 2; NAIP, neuronal apoptosis inhibitory protein; XIAP, X-linked inhibitors of apoptosis protein.