Table 4.
Mean mRNA expression of the five inhibitors of apoptosis family members and p53 for 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal-pouch squamous-cell carcinogenesis
| Untreated | Mineral oil-treated | 3-week DMBA-treated* | 7-week DMBA-treated* | 14-week DMBA-treated* | |
|---|---|---|---|---|---|
| cIAP1 | 0.1108 ± 0.0365 | 0.2008 ± 0.0640 | 0.1518 ± 0.0602 | 0.3590 ± 0.0951 | 0.6313 ± 0.1166 |
| cIAP2 | 0 | 0 | 0.1293 ± 0.0325 | 0.2124 ± 0.0670 | 0.2759 ± 0.0887 |
| NAIP | 0.4264 ± 0.2456 | 0.4935 ± 0.0599 | 0.7286 ± 0.2263 | 0.9867 ± 0.2868 | 1.9495 ± 0.4451 |
| XIAP | 0.1294 ± 0.0376 | 0.3042 ± 0.1266 | 4.3607 ± 0.5956 | 4.6138 ± 0.5818 | 5.3556 ± 0.9270 |
| Survivin | 0 | 0 | 1.3858 ± 0.5409 | 2.3059 ± 0.3641 | 1.1561 ± 0.2815 |
| p53 | 0 | 0 | 0.1227 ± 0.0382 | 1.0079 ± 0.2870 | 1.9559 ± 0.3381 |
*
Statistical significance as compared with untreated or mineral oil-treated tissues with the exception for comparison of the average mRNA expression in mineral oil-treated tissues for cIAP1 with that for the 3 weeks DMBA-treated tissues (P < 0.0001, one-way anova).
cIAP1, cellular inhibitors of apoptosis protein 1; cIAP2, cellular inhibitors of apoptosis protein 2; NAIP, neuronal apoptosis inhibitory protein; XIAP, X-linked inhibitors of apoptosis protein.