Table 1.

In vivo physiological parameters

Group	Breaths/min	Pleural effusion	Lactate	PO2	PSAP	RVPSP
Veh D1	90 ± 3	ND	1 ± 0.1	83 ± 6	128 ± 4	30 ± 1
PE D1	141 ± 9*	8.3 ± 1.5*	2.8 ± 0.4*	62 ± 5*	93 ± 14*	36 ± 3*
PE D4	105 ± 2*	ND	1.7 ± 0.4	61 ± 6*	119 ± 5	38 ± 2*
PE W1	101 ± 4	ND	0.9 ± 0.2	69 ± 2	131 ± 5	34 ± 3
PE W2	95 ± 5	ND	0.4 ± 0.1	76 ± 3	140 ± 6	31 ± 2
PE W4	90 ± 3	ND	0.9 ± 0.1	67 ± 2	145 ± 7	32 ± 2
PE W6	95 ± 5	ND	0.8 ± 0.1	70 ± 3	146 ± 5	32 ± 2
Veh W6	94 ± 4	ND	0.1 ± 0.1	86 ± 4	135 ± 6	28 ± 2

ND, none detected; PSAP, peak systolic arterial pressure (mmHg); RVPSP, right ventricular peak systolic pressure (mmHg).

^*Significant difference from vehicle day 1. n = 8–10/group.