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. 2008 Jul 24;586(Pt 18):4517–4530. doi: 10.1113/jphysiol.2008.156984

Figure 5. Pharmacological modulation of the jejunal afferent fibre response to mechanical stimulation.

Figure 5

A, bath application of granisetron (30 μm) resulted in a significant decrease in the mechanosensitivity of controls (P = 0.0001, n = 11), d28–36PI (P < 0.0001, n = 8) and d48–56PI (P < 0.0001, n = 7) preparations (*P < 0.05; ** P < 0.01, Bonferroni post hoc analysis). Mechanosensitive responses recovered upon removal of granisetron. B, the decrease in afferent firing with 30 μm granisetron during ramp distension (0–60 mmHg) is greater in the d28–36PI preparations compared to both controls and d48–56PI preparations (* P < 0.001, one-way ANOVA with Tukey's post hoc test). C, 30 μm granisetron blocks the low threshold response (0–20 mmHg) in the d28–36PI preparations compared to both controls and d48–56PI preparations (* P < 0.05, one-way ANOVA with Tukey's post hoc test). D, 30 μm granisetron blocks the high threshold response (20–60 mmHg) in both the d28–36PI preparations and d48–56PI preparations compared to controls (* P < 0.05, one-way ANOVA with Tukey's post hoc test).