Table 2.

RGC death or atrophy in diabetic rats

Model	Duration	Method	Reference
STZ rats	8–12 weeks	% of optic nerve axons	Scott et al. 1986
BB/W rats	12 months	Decrease in diameter but not density of optic nerve axons	Sima et al. 1992
STZ rats	7.5 months	TUNEL, RGC count	Barber et al. 1998
STZ rats	1–12 months	NeuN immunohistochemistry	Zeng et al. 2000
STZ rats	4 weeks	TUNEL	El-Remessy et al. 2006
STZ rats	12 weeks	TUNEL	Seigel et al. 2006
STZ rats	3 months	Thy-1 immunostain	Qin et al. 2006
STZ rats	4–5 weeks	Retrograde dye	Kusari et al. 2007
STZ rats	9 months	Count RGC	Zheng et al. 2007b