Figure 1. Effect of electron transport chain inhibitors on spontaneous Ca²⁺ waves in urethra ICC.

Aa shows a pseudo-line-scan image of spontaneous Ca²⁺ waves from an isolated ICC in the absence and presence of antimycin A (5 μm). Ab shows an intensity profile plot of this activity measured over the entire image. Summary graphs of the effects of antimycin A on mean frequency (min⁻¹) of Ca²⁺ waves and on basal Ca²⁺ levels (F/F₀) are shown in Ac. Ba–c show that rotenone produces similar effects to antimycin A.