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. 2008 Aug 14;586(Pt 19):4693–4707. doi: 10.1113/jphysiol.2008.158931

Figure 1. D1 receptor activation inhibits whole cell NMDA receptor currents recorded from 7 day-old rat striatal neurons.

Figure 1

A, response to NMDA (10 μm) and glycine (10 μm) applied for 2 min, followed by 5 min SKF-82958 (20 nm) and spiperone (2 nm), and finally NMDA (10 μm), glycine (10 μm), SKF-82958 (20 nm) and spiperone (2 nm) for 2 min. Brief downward deflections of the current trace show occasional miniature synaptic currents. B, response to NMDA and glycine applied for 2 min, followed by 5 min of control recording solution, followed by NMDA and glycine for 2 min. C, response to NMDA (10 μm) and glycine (10 μm) applied for 2 min, followed by 5 min SKF-82958 (20 nm), SCH-23390 (300 nm) and spiperone (2 nm), and finally NMDA (10 μm), glycine (10 μm), SKF-82958 (20 nm), SCH-23390 (300 nm) and spiperone (2 nm) for 2 min. D, mean percentage change (±s.e.m.) in NMDA current in the presence of SKF-82598 and spiperone (unpaired t test P < 0.05), in the presence of SKF-82598, spiperone and SCH-23390, and from control experiments involving two successive NMDA responses.