Table 2. Association results for variants in Omi/HtrA2 gene and PD.
For the matched US and Irish series, estimated odds ratios and P-values result from single variable conditional logistic regression models. For the Norwegian and Polish series, estimated odds ratios and P-values result from logistic regression models adjusted for age and gender. Estimated odds ratios correspond to an increase of one minor allele. P-values ≤ 0.01 are considered statistically significant after a Bonferroni adjustment for multiple testing.
| Series/ SNP | US | Ireland | Norway | Poland | ||||
|---|---|---|---|---|---|---|---|---|
| Patient n (%) | Control n (%) | Patient n (%) | Control n (%) | Patient n (%) | Control n (%) | Patient n (%) | Control n (%) | |
| rs10779958 | ||||||||
| AA | 162 | 150 | 137 | 126 | 283 | 672 | 78 | 96 |
| AC | 58 | 69 | 42 | 54 | 101 | 270 | 20 | 24 |
| CC | 6 | 4 | 5 | 5 | 6 | 16 | 3 | 2 |
| A | 364 | 353 | 316 | 306 | 667 | 1614 | 176 | 216 |
| C | 64 (15) | 75 (18) | 52 (14) | 64 (17) | 113 (14) | 302 (16) | 26 (13) | 28 (11) |
| OR (95% CI) | 0.84 (0.59, 1.19) | 0.80 (0.55, 1.17) | 0.93 (0.73, 1.19) | 1.29 (0.72, 2.32) | ||||
| P-value | 0.33 | 0.25 | 0.56 | 0.39 | ||||
|
| ||||||||
| rs2231250 | ||||||||
| GG | 159 | 150 | 137 | 125 | 284 | 671 | 78 | 96 |
| GC | 56 | 67 | 43 | 54 | 95 | 266 | 20 | 24 |
| CC | 6 | 4 | 5 | 5 | 6 | 17 | 3 | 2 |
| G | 356 | 351 | 317 | 304 | 663 | 1608 | 176 | 216 |
| C | 62 (15) | 73 (17) | 53 (14) | 64 (17) | 107 (14) | 300 (16) | 26 (13) | 28 (11) |
| OR (95% CI) | 0.82 (0.57, 1.17) | 0.82 (0.56, 1.19) | 0.88 (0.69, 1.13) | 1.29 (0.72, 2.32) | ||||
| P-value | 0.28 | 0.29 | 0.32 | 0.39 | ||||
|
| ||||||||
| rs1183739 | ||||||||
| GG | 124 | 153 | 109 | 132 | 266 | 625 | 70 | 75 |
| GC | 56 | 56 | 62 | 42 | 97 | 245 | 25 | 38 |
| CC | 5 | 6 | 6 | 5 | 9 | 24 | 1 | 3 |
| G | 287 | 346 | 280 | 306 | 629 | 1233 | 165 | 188 |
| C | 63 (18) | 66 (16) | 74 (21) | 52 (15) | 115 (15) | 293 (19) | 27 (14) | 44 (19) |
| OR (95% CI) | 1.14 (0.76, 1.71) | 1.70 (1.09, 2.65) | 0.95 (0.75, 1.20) | 0.68 (0.39, 1.20) | ||||
| P-value | 0.54 | 0.02 | 0.65 | 0.18 | ||||
|
| ||||||||
| ss102660598 (G421T) | ||||||||
| GG | 199 | 204 | 166 | 169 | 344 | 842 | 91 | 110 |
| GT | 25 | 19 | 18 | 15 | 28 | 102 | 8 | 11 |
| TT | 1 | 0 | 0 | 0 | 0 | 4 | 0 | 0 |
| G | 402 | 409 | 350 | 353 | 716 | 1786 | 190 | 231 |
| T | 24 (6) | 19 (4) | 18 (5) | 15 (4) | 28 (4) | 110 (6) | 8 (4) | 11 (5) |
| OR (95% CI) | 1.31 (0.69, 2.52) | 1.20 (0.61, 2.38) | 0.67 (0.43, 1.02) | 1.00 (0.37, 2.72) | ||||
| P-value | 0.41 | 0.6 | 0.06 | 0.99 | ||||
|
| ||||||||
| rs2241028 | ||||||||
| GG | 200 | 198 | 161 | 155 | 351 | 827 | 91 | 111 |
| GA | 23 | 23 | 25 | 30 | 36 | 120 | 10 | 12 |
| AA | 1 | 1 | 0 | 0 | 1 | 4 | 0 | 0 |
| G | 403 | 402 | 347 | 340 | 738 | 1774 | 192 | 234 |
| A | 21 (5) | 24 (6) | 25 (7) | 30 (8) | 38 (5) | 128 (7) | 10 (5) | 12 (5) |
| OR (95% CI) | 0.83 (0.46, 1.51) | 0.83 (0.48, 1.42) | 0.74 (0.50, 1.07) | 1.15 (0.46, 2.90) | ||||
| P-value | 0.55 | 0.49 | 0.11 | 0.76 | ||||