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. 2009 Jan 9;5(1):e1000331. doi: 10.1371/journal.pgen.1000331

Figure 3. Genome-wide genetic linkage analysis of loci affecting urethane-induced lung tumor multiplicity.

Figure 3

(A) (BALB/c×C3H/He)F2 cross detects the Pas1 locus at LOD score = 18.4. (B) (A/J×C3H/He)F2 cross detected the Pas1 locus at LOD score = 18.7. Red curves indicate the results of the composite interval mapping, whereas black curves indicate the results of genome scan using the Kras genotype as covariate (conditioning on the Pas1 alleles). Horizontal lines indicate the threshold values (α = 0.05) of the LOD score. The Clas2 locus (Chromosome 4) showed no significant linkage, despite the presence of the claimed functional polymorphism (D102E) in both crosses. No other locus detected by whole-genome strain survey showed significant linkage.