. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Hum Immunol. 2008 Sep 21;69(11):781–789. doi: 10.1016/j.humimm.2008.08.283

Table 1.

Known subtypes of inhibitory CD8⁺ T cells

Described CD8+ suppressor T cell	Species	Natural or Adaptive	Induction	Mechanism of suppression	Reference
CD8⁺CD28⁻Foxp3⁺	human	adaptive	Allogeneic, xenogeneic, or antigen-pulsed autologous APC	Induction of ILT3 and ILT4 on APC	[10–12]
CD8⁺CD103⁺	human	adaptive	Alloantigen	Cell contact dependent	[13]
CD8⁺CD25⁺ CD28⁺Foxp3⁺	human	adaptive	Staphylococcal Enterotoxin B or Anti-CD3	Cell contact dependent	[14]
CD8⁺CD25⁺CTLA-4⁺Foxp3⁺	human	adaptive	Modified anti -CD3	Cell contact dependent	[15]
CD8⁺CD25⁺CD28⁻CTLA-4⁺Foxp3⁺	human	adaptive	Autologous LPS-activated DC	CTLA-4 dependent	[16]
CD8⁺IL-10⁺	human	adaptive	CD40 ligand-activated plasmacytoid DC	IL-10 secretion	[17]
CD8⁺CCR7⁺CD45RO⁺IL-10⁺	human	adaptive	Tumor-ascites derived plasmacytoid DC	IL-10 secretion	[18]
CD8⁺	human	adaptive	IL-2 and TGFβ		[19]
CD8⁺CD103⁺CTLA-4⁺Foxp3⁺GITR⁺	human	adaptive	Virus peptide-pulsed APC	Cell contact dependent	[20]
CD8⁺CD25⁺Foxp3⁺LAG3⁺	human	adaptive	Bacillus Calmette-Guérin’s stimulation	CCL4 secretion	[21]
Nonantigen-specific CD8⁺CD28⁻	human	adaptive	Monocytes, GM-CSF, and IL-2 or IL-10 and IL-2	IL-10 secretion	[23, 24, 55]
CD8⁺CD25⁺CTLA-4⁺GITR⁺Foxp3⁺	human	natural		TGFβ- and CTLA-4-dependent	[25]
CD8⁺CD28⁻CD56⁺	human	adaptive	Allogeneic APC	Downregulation of CD80 and CD86 expression on APC	[48]
CD8⁺IL-16⁺	human		in RA synovium	IL-16 secretion	[49]
CD8⁺CD122⁺	mouse	natural		IL-10 secretion	[26–28, 75]
CD8⁺CD11c⁺	mouse	adaptive	Anti-4-1 BB mAb	IFNγ-mediated induction of IDO in monocytes and DC	[53]
CD8⁺Foxp3⁺PD-1⁺TGFβ⁺	mouse	adaptive	Antigen specific stimulation	Major mechanism: TGFβ-Foxp3-PD1 axis; Minor mechanism: Cytotoxicity via Granzyme B	[60–62]
CD8⁺CD62L⁺GITR⁺TGFβ⁺	mouse	adaptive	Antigen-specific stimulation	TGFβ secretion	[63]
CD8⁺	mouse	adaptive	IL-2 and TGFβ	Partially TGFβ dependent	[64]
CD8⁺CD45RO⁺CD101⁺CD103⁺	mouse	adaptive	Allogeneic intestinal epithelial cells	Cell contact dependent	[68, 69]
CD8⁺CD44⁻CD103⁺	mouse	adaptive	in TNF ΔARE mice	TGFβ secretion	[72]
CD8⁺CD28⁻	mouse	adaptive		in vitro: cell contact dependent in vivo: IL-10 and TGFβ dependent	[73]
CD8⁺CD28⁻ Foxp3⁺	mouse	adaptive	Antigen-specific stimulation		[77]

Abbreviations: APC = antigen presenting cells; ILT = immunoglobulin-like transcript; DC = dendritic cells; RA = rheumatoid arthritis; IDO = indoleamine 2,3-dioxygenase; ARE = AU-rich region