TABLE 4.
Developmental Outcomesa
| Sidestream Smoke Exposure on Gestational Days 6–9
| ||
|---|---|---|
| Outcome | Shamb | CSEb,c |
| Number of Implantations | ||
| Folr2+/+ | 11.3 ± 0.6 | 10.5 ± 0.4 |
| Folr2−/− | 9.8 ± 0.8 | 10.8 ± 0.5 |
| Number of Resorptions | ||
| Folr2+/+ | 0.4 ± 0.2 | 1.1 ± 0.7 |
| Folr2−/− | 0.5 ± 0.3 | 1.5 ± 0.5 |
| Somite Number | ||
| Folr2+/+ | 33.4 ± 0.4 | 32.1 ± 1.2 |
| Folr2−/− | 32.3 ± 0.8 | 31.3 ± 0.9 |
| Number of Abnormalities | ||
| Folr2+/+ | 0.7 ± 0.3 | 1.0 ± 0.4 |
| Folr2−/− | 0.3 ± 0.2 | 0.5 ± 0.3 |
| Crown-Rump Length (mm) | ||
| Folr2+/+ | 12.2 ± 0.2 | 12.3 ± 0.6 |
| Folr2−/− | 11.7 ± 0.4d | 11.3 ± 0.4d |
a
Developmental outcomes were assessed on gd 10.5.
b
Outcome data are reported as mean ± SEM for each measure (n = 7–9 litters per group).
c
CSE = Cigarette Smoke Exposure
d
Folr2−/− embryos have a reduced crown-rump length compared to Folr2+/+ embryos regardless of treatment condition (p < 0.05).