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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Alcohol. 2008 May 27;42(5):349–361. doi: 10.1016/j.alcohol.2008.03.131

Figure 4. Role of TNF-α in intestinal barrier function.

Figure 4

In intestinal inflammatory diseases, TNF-α may play an important role in impairing intestinal barrier function by upregulating the activity of myosin light-chain kinase (MLCK) and associated increased phosphorylation of myosin light-chain (MLC).