Figure 2.

Decomposition of coevolution. Coevolution between two amino acid sites (C_ij) can be decomposed into phylogenetic coevolution (C_phylogeny), structural coevolution (C_structure), functional coevolution (C_function), coevolution due to atomic interaction (C_interaction) and stochastic coevolution (C_stochastic). Sites examined for coevolution are highlighted as colour stars in the multiple sequence alignment (group of horizontal lines). Dashed vertical lines separate different coevolutionary components. The different sequences (horizontal lines) are phylogenetically related following the topology shown.