Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Feb 14;4:29–38.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2008 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

PMC Copyright notice

Algorithm diagram for coevolution methods based on the correlation of distance matrices. Multiple sequence alignments are used to estimate different kind of distance matrices, which are compared afterwards. A_i and B_i symbolise either the distance between two amino acid sites within the multiple sequence alignment or the distance between two proteins. The correlation between matrices together with the phylogenetic congruence are used to test coevolution between amino acid sites or proteins.