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. 2008 Apr 28;4:153–169. doi: 10.4137/ebo.s705

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Copyright © 2008 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

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According to procedure used in type-I analysis, the multiple alignments of each RAMP group were processed by DIVERGE 2.0 (Wang and Gu, 2001) to collect type-II functional divergence data. The posterior ratios retrieved from this analysis were plotted separately for each group. The dashed line shows the threshold value for significant residues under type-II functional divergence. mRAMP = RAMP proteins from mammals. fRAMP = RAMP proteins from fishes. White, grey, and black bars show the scores for the RAMP1/RAMP2, RAMP1/RAMP3, and RAMP2/RAMP3 pairwise comparisons respectively. Secondary structures are defined for each group; non homogeneous distribution was caused by loss of type-II information for some residues.