Table 1.
Comparison of biomarkers in paired primary and metastatic pairs. Markers were determined to be either concordant or discordant, and if discordant, the direction of discordance is indicated. The significance of these differences, based on a 2-sided t-test, is shown.
| marker |
concordant (positive) |
concordant (negative) |
discordant |
2-sided t-test |
|
|---|---|---|---|---|---|
| higher in primary |
higher in met |
P-value |
|||
| E-cadherin |
18 |
0 |
20 |
3 |
<0.01 |
| TTF-1 |
13 |
10 |
15 |
3 |
<0.01 |
| p-AKT |
26 |
0 |
5 |
10 |
0.28 |
| p-S6 | 20 | 0 | 1 | 20 | <0.01 |