Skip to main content
. Author manuscript; available in PMC: 2009 Jan 6.
Published in final edited form as: Cell Microbiol. 2008 Apr 21;10(8):1735–1745. doi: 10.1111/j.1462-5822.2008.01163.x

Figure 7.

Figure 7

A. The espF point mutant L16E (Leu16→Glu) prevents targeting of EspF to mitochondria and the associated induction of cell death pathways. Loss of mitochondrial targeting does not impair the ability of EspF to reduce NHE3 activity. B. NHE3 is recycled from the surface to subapical membrane domains. EspF is known to interact with SNX9 which is involved in vesicle trafficking via its proline rich repeat domain. A triple point mutant which replaces Arg75,122,169 with Asp also known as EspF-D3 was used to test the role of SNX9 in alteration of NHE3 activity. n = 4, performed in triplicate. * = significant from uninfected by Student’s t test.