Table 4.

Univariate and multivariate Cox regression analyses of PSA relapse.

	Univariate analyses	Multivariate analyses
		Base model	Base model + CyclinD1+/ErbB3+(T)	Base model + Ebp1+/CyclinD1-(T)
	Hazard ratio (95% CI); p	Hazard ratio (95% CI); p	Hazard ratio (95%CI); p	Hazard ratio (95%CI); p
Gleason < 7 vs Gleason 7	1.67	0.99	0.96	1.36
	(0.78–3.57);	(0.45–2.19);	(0.43–2.17);	(0.58–3.20);
	p = 0.186	p = 0.977	p = 0.924	p = 0.484
Gleason < 7 vs Gleason > 7	2.80	4.21	5.75	6.80
	(1.15–6.81);	(1.65–10.75):	(2.14–15.44);	(2.40–19.30):
	p = 0.023	p = 0.030	p < 0.001	p < 0.001
Pre-Op PSA	1.03	..	..	..
	(0.99–1.07);	..	..	..
	p = 0.198	..	..	..
Surgical Margins	5.97	8.06	9.91	12.06
	(2.68–13.3);	(3.32–19.55);	(3.96–24.81);	(4.48–32.49);
	p < 0.001	p < 0.001	p < 0.001	p < 0.001
P-Stage	5.15	..	..	..
	(2.49–10.63);	..	..	..
	p < 0.001	..	..	..
Molecular Marker	..	..	0.44	4.79
	..	..	(0.20–0.94);	(1.73–13.26);
	..	..	p = 0.034	p = 0.003
Model P value	..	p < 0.001	p < 0.001	p < 0.001

Correlation between PSA relapse and the clinico-pathological parameters using univariate Cox regression analyses. Multi-variate Cox regression analysis of the base models and the base model + molecular marker.

* Multi-Variate COX regression was perform under the Forward Wald model

Normal Adjacent Tissues (NA): Tumor Tissues (T)