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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Hepatology. 2009 Jan;49(1):87–96. doi: 10.1002/hep.22578

Fig. 3.

Fig. 3

HFD-induced steatohepatitis is decreased in jnk1-/- mice whereas liver injury increased in jnk2-/- mice. (A) Histological steatosis grade in HFD-fed wild-type (WT), jnk1-/- and jnk2-/- mice (n=7-12; *P<0.0001 compared to wild-type or jnk2-/- mice). (B) TG content in the livers of regular diet (RD)- and HFD-fed wild-type, jnk1-/- and jnk2-/- mice (n=6-15; *P<0.01 compared to RD-fed wild-type mice; **P<0.0003 compared to jnk1-/- or jnk2-/- HFD-fed mice). (C) Serum ALT levels from the same animals (n=5-13; *P<0.001 as compared to RD-fed wild-type mice; **P<0.0001 as compared to HFD-fed wild-type mice; §P<0.01 when compared to HFD-fed wild-type or jnk1-/- mice). (D) Percentage of TUNEL positive cells in the same livers (n=5-9; *P<0.0001 compared to RD-fed wild-type mice; **P<0.00001 compared to wild-type or jnk2-/- HFD-fed mice; §P<0.005 compared to HFD-fed wild-type mice). (E) Histological inflammation grade in HFD-fed wild-type, jnk1-/- and jnk2-/- mice (n=7-12; *P<0.02 compared to wild-type or jnk2-/- mice).