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JNK2 ASO treatment of HFD-fed mice results in increased Bim and Bax expression. Total protein isolated from the livers of HFD-fed mice treated with PBS, or control (Con), JNK1 or JNK2 ASO was immunoblotted for total JNK, Bim, Ser65 phospho-Bim (P-Bim), Bax, Bad, Mcl-1, caspase 3 (Casp 3), caspase 7 (Casp 7) or PDI. Arrows indicate the p54 and p46 forms of JNK, BimEL and BimL and the cleaved fragments of caspase 3 and 7. Results are representative of three independent experiments.
