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Hepatic mitochondrial Bim and Bax translocation and cytochrome c release occur in JNK2 ASO-treated HFD-fed mice. Mitochondrial (A) and cytoplasmic (B) protein fractions were isolated from HFD-fed mice administered a control (Con), JNK1 or JNK2 ASO. Proteins were immunoblotted with antibodies for Bim, Bax, Bid, Bad and cytochrome c (cyt c). Stripped blots were reprobed for cytochrome oxidase (cyt ox) and PDI as indicated.
