Table 2.

Incidence of grade 3 to grade 4 hematologic toxicity, per age interval and per taxane

	Docetaxel	Paclitaxel	Total	P value, docetaxel versus paclitaxel
Leukopenia
Patients aged < 60 years	1,534 (59.6)	196 (35.3)	1,730 (55.3)	<0.001
Patients aged 60 to 64 years	351 (68.3)	55 (45.8)	406 (64.0)	<0.001
Patients aged > 64 years	234 (69.2)	38 (49.4)	272 (65.5)	0.001
P value	<0.001	0.011	<0.001
Neutropenia
Patients aged < 60 years	926 (47.4)	226 (44.8)	1,152 (46.9)	0.321
Patients aged 60 to 64 years	273 (57.6)	53 (48.6)	326 (55.9)	0.111
Patients aged > 64 years	190 (59.2)	35 (49.3)	225 (57.4)	0.164
P value	<0.001	0.643	<0.001
Febrile neutropenia
Patients aged <60 years	179 (7.2)	2 (0.4)	181 (6.1)	<0.001
Patients aged 60 to 64 years	40 (8.1)	3 (2.8)	43 (7.2)	0.085
Patients aged > 64 years	28 (8.7)	1 (1.4)	29 (7.4)	0.061
P value	0.560	0.049	0.430
Anemia
Patients aged < 60 years	57 (2.2)	40 (7.2)	97 (3.1)	<0.001
Patients aged 60 to 64 years	12 (2.3)	4 (3.3)	16 (2.5)	0.756
Patients aged > 64 years	12 (3.6)	2 (2.6)	14 (3.4)	0.946
P value	0.315	0.110	0.674
Thrombopenia
Patients aged < 60 years	44 (1.7)	26 (4.7)	70 (2.3)	<0.001
Patients aged 60 to 64 years	13 (2.5)	1 (0.8)	14 (2.2)	0.432
Patients aged > 64 years	21 (6.2)	0 (0.0)	21 (5.1)	0.050
P value	<0.001	0.025	0002

Data presented as n (%). All percentage values are valid. P values all for incidence of difference between age groups.