Table 2.
Distribution of Chk1 staining category according to clinico-pathological parameters
| Chk1 fraction positive nuclei (%) | ||||
| Variable | 0 to 5 (n = 108) | 6 to 50 (n = 192) | 51 to 100 (n = 41) | P value |
| Tumor type | 0.001a | |||
| Ductal | 94 | 168 | 32 | |
| Lobular | 10 | 3 | 2 | |
| Medullary | 1 | 15 | 6 | |
| Missing cases: 169 | ||||
| Tumor size (mm) | 0.012b | |||
| ≥20 | 48 | 64 | 10 | |
| >20 | 60 | 127 | 31 | |
| Missing cases: 160 | ||||
| Lymph node status | 0.131b | |||
| Negative | 24 | 54 | 14 | |
| Positive | 83 | 138 | 27 | |
| Missing cases: 160 | ||||
| NHG | <0.001c | |||
| I | 18 | 14 | 0 | |
| II | 67 | 66 | 3 | |
| III | 20 | 106 | 36 | |
| Missing cases: 170 | ||||
| Ki67 positive (%) | <0.001c | |||
| 0 to 10 | 70 | 55 | 2 | |
| 11 to 25 | 19 | 61 | 5 | |
| 26 to 100 | 10 | 52 | 32 | |
| Missing cases: 194 | ||||
aKruskal-Wallis test (two-sided). bMann-Whitney test (two-sided). cSpearman's ρ. Chk1, checkpoint kinase 1; NHG, Nottingham Histological Grade.