Table 3.
Protein expression | Gene expression | ||||
Deletion | Normal | Gain/Amp | Total | P valuea | |
Cortactin | 0.664 | ||||
Low/intermediate expression | 1 | 13 | 5 | 19 | |
Over-expression | 0 | 6 | 3 | 9 | |
Total | 1 | 19 | 8 | 28 | |
FADD | 0.477 | ||||
Low/intermediate expression | 0 | 16 | 7 | 23 | |
Over-expression | 0 | 3 | 3 | 6 | |
Total | 0 | 19 | 10 | 29 | |
Cyclin D1 | 0.083 | ||||
Low/intermediate expression | 3 | 30 | 10 | 43 | |
Over-expression | 0 | 1 | 3 | 4 | |
Total | 3 | 31 | 13 | 47 | |
Pak1 | 0.027 | ||||
Negative | 3 | 28 | 4 | 35 | |
Positive | 0 | 4 | 5 | 9 | |
Total | 3 | 32 | 9 | 44 | |
Chk1 | 0.241b | ||||
0% to 5% (low) | 2 | 6 | 0 | 8 | |
6% to 50% (intermediate) | 5 | 18 | 0 | 23 | |
51% to 100% (high) | 0 | 7 | 0 | 7 | |
Total | 7 | 31 | 0 | 38 |
aCorrelations were calculated using Mann-Whitney test (two-sided) unless otherwise specified. bSpearman's ρ. Amp, amplification; CGH, comparative genomic hybridization; Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; Pak1, p21-activated kinase 1.