Table 1.

In a multivariate analysis of recurrent breast cancer cases, the expression of YB-1 was better than HER-2 or ER in predicting events

Prognostic marker	Patients with relapse
	HR (95% CI)	P value
Nodal status
Positive versus negative	1.951 (1.725 to 2.206)	1.7 × 10-26
Tumor size (cm)
2 to 5	1.392 (1.227 to 1.579)	2.8 × 10-7
>5	1.921 (1.227 to 2.445)	1.2 × 10-7
Grade
III versus II versus I	1.300 (1.139 to 1.482)	9.6 × 10-5
Age (years)
<50 versus ≥ 50	1.000 (0.878 to 1.139)	1.000
ER
Positive versus negative	0.942 (0.816 to 1.087)	0.41
HER-2
Positive versus negative	1.256 (1.066 to 1.479)	6.0 × 10-3
YB-1
Positive versus negative	1.331 (1.169 to 1.516)	1.6 × 10-5

The predictive power of YB-1 was similar to that of tumor grade and smaller tumor size, but not as great as that of nodal status. CI, confidence interval; ER, estrogen receptor; HER, human epidermal growth factor receptor; HR, hazard ratio; YB-1 = Y-box binding protein-1.