Table 2.
Manual analysis threshold | 10% automated threshold | RFC threshold | |||||||
HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
Cohort I (n = 179) | |||||||||
ER | |||||||||
OS | 0.259 | 0.127 to 0.530 | 0.001 | 0.154 | 0.067 to 0.355 | 0.002 | 0.235 | 0.116 to 0.473 | 0.001 |
PR | |||||||||
OS | 0.307 | 0.158 to 0.597 | 0.001 | 0.361 | 0.183 to 0.712 | 0.01 | 0.386 | 0.197 to 0.756 | 0.02 |
Cohort II (n = 564) | |||||||||
ER | |||||||||
OS | 0.62 | 0.465 to 0.826 | 0.006 | 0.68 | 0.509 to 0.907 | 0.009 | 0.631 | 0.480 to 0.830 | 0.001 |
BCSS | 0.677 | 0.494 to 0.928 | 0.006 | 0.664 | 0.492 to 0.898 | 0.008 | 0.592 | 0.445 to 0.787 | < 0.001 |
RFS | 0.714 | 0.540 to 0.943 | 0.009 | 0.797 | 0.603 to 1.054 | 0.11 | 0.701 | 0.538 to 0.914 | 0.009 |
PR | |||||||||
OS | 0.647 | 0.483 to 0.867 | 0.004 | 0.719 | 0.538 to 0.961 | 0.026 | 0.705 | 0.524 to 0.947 | 0.020 |
BCSS | 0.602 | 0.445 to 0.814 | 0.001 | 0.7 | 0.518 to 0.947 | 0.020 | 0.673 | 0.495 to 0.916 | 0.012 |
RFS | 0.73 | 0.549 to 0.972 | 0.03 | 0.797 | 0.603 to 1.053 | 0.790 | 0.791 | 0.593 to 1.054 | 0.109 |
HR, hazard ratio; CI, confidence interval; OS, overall survival; BCSS, breast cancer-specific survival; RFS, recurrence-free survival.