Table 2.
Body weights and echocardiographic analysis
| Before TAC |
After TAC |
|||
|---|---|---|---|---|
| Day 7 | Day 21 | Day 28 | ||
| Body weight, g | ||||
| SD | 26.5±0.2 | 24.9±0.5* | 26.5±0.3 | 27.5±0.4 |
| HFD | 26.7±0.4 | 23.7±0.7* | 27.1±0.3 | 28±0.3 |
| HR, beats/min | ||||
| SD | 643±14 | 582±21 | 593±12 | 636±11 |
| HFD | 638±24 | 638±29 | 608±15 | 608±35 |
| LVIDED, mm | ||||
| SD | 3.1±0.1 | 3.4±0.1 | 3.5±0.1 | 3.4±0.1 |
| HFD | 3.3±0.1 | 3.6±0.1* | 3.6±0.1* | 3.9±0.1*† |
| LVIDES, mm | ||||
| SD | 1.4±0.0 | 1.8±0.1 | 1.8±0.1 | 1.9±0.1* |
| HFD | 1.5±0.1 | 2.3±0.1*† | 2.4±0.1*† | 2.7±0.2*† |
| FS, % | ||||
| SD | 54±1 | 47±2 | 47±2 | 45±2* |
| HFD | 56±1 | 36±2*† | 35±2*† | 31±3*† |
| PWT, mm | ||||
| SD | 0.8±0.02 | 0.9±0.03 | 1.1±0.03* | 1.0±0.04* |
| HFD | 0.8±0.00 | 1.0±0.07* | 1.1±0.06* | 1.2±0.06* |
| LV mass, mg | ||||
| SD | 72±2 | 102±5* | 135±7* | 121±7* |
| HFD | 82±4 | 109±10* | 149±16* | 177±15*† |
Values are means ± SE; n = 12 for SD-fed mice and n = 7 for HFD-fed mice. TAC, transverse aortic constriction; HR, heart rate; LVIDED, left ventricular end-diastolic internal diameter; LVIDES, left ventricular end-systolic internal diameter; FS, fractional shortening; PWT, left ventricular posterior wall thickness; LV mass, left ventricular mass.
*
P < 0.05 vs. before TAC.
†
P < 0.05 vs. SD at the same time point.