Table 3.
Hemodynamic parameters 28 days after TAC in SD- and HFD-fed mice
| SD | HFD | |
|---|---|---|
| HR, beats/min | 636±15 | 585±15 |
| LVESP, mmHg | 174±4 | 126±7* |
| LVEDP, mmHg | 5±1 | 5±1 |
| SAPL, mmHg | 103±6 | 83±7* |
| TSPG, mmHg | 70±4 | 43±9* |
| dP/dtmax, mmHg/s | 13,993±1,094 | 8,246±565* |
| dP/dtmin, mmHg/s | −13,636±787 | −8,575±695* |
| dP/dtmax/IP, s−1 | 174±10 | 141±6* |
| PAMP, nW/μl2 × 104 | 360±65 | 180±27* |
| Ea, mmHg/μl | 9.4±1.6 | 10.2±1.8 |
| τ, ms | 5.1±0.3 | 6.6±0.3* |
Values are means ± SE; n = 10 for SD mice and n = 10 for HFD mice 28 days after TAC. LVESP, LV end-systolic pressure; LVEDP, LV end-diastolic pressure; SAPL, systolic arterial pressure measured in the left carotid artery; TSPG, transstenotic pressure gradient; dP/dtmax, maximum rate of developed LV pressure; dP/dtmin, minimum rate of developed LV pressure; dP/dtmax/IP, ratio of maximum rate of developed LV pressure to the instantaneous pressure at this time point; PAMP, preload adjusted maximum power; Ea, arterial elastance; τ, time constant of isovolumic relaxation.
*
P < 0.05 vs. SD.