Fig. 3.
Implantation of cardiogenic cells on an extracellular matrix (ECM) patch in the canine right ventricle (RV) enhances mechanical function. A: representative plots of regional stroke work (RSW) from baseline, scaffold seeded with hMSCs, and scaffold seeded with cardiogenic cells (Cardiogenic). The direction of the work loop is indicated by the arrow. B: regional mechanical function, as assessed by systolic contraction (SC) and RSW, was improved in cardiogenic-seeded scaffolds compared with hMSC-seeded scaffolds. Aendsystole, area at the end of systole; P × A, RV pressure × regional area; n, sample size.