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Effect of chronic inhibition of the synthesis of 20-HETE with HET0016 (10 mg·kg−1·day−1 sc for 2 days) on vascular reactivity of serotonin-preconstricted middle cerebral arteries to ACh in SHRSP. †Significant difference from the corresponding value in WKY rats; ‡significant difference from corresponding control value within a strain; *significant difference from corresponding values in HET0016-treated SHRSP. l-NAME, NG-nitro-l-arginine-methyl ester.
