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Intracoronary infusion of adult MSCs (aMSCs) provided significantly better cardioprotection compared with neonatal MSCs (nMSCs). This was seen in end-diastolic pressure (EDP; A), cardiac contractility (+dP/dt; B), and rate of myocardial relaxation (−dP/dt; C) at end reperfusion. These data allowed for the important appreciation that an age threshold may exist as to when stem cells can provide beneficial tissue protection (n = 5 animals/group).
