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Infusion of aMSCs that were transfected with VEGF siRNA significantly impaired postischemic myocardial recovery. End-diastolic pressure (A) was higher, and +dP/dt (B) and −dP/dt (C) were lower during reperfusion after the application of MSCs treated with VEGF siRNA compared with Scramble siRNA groups. No differences in myocardial function were observed between Scramble siRNA-transfected and nontransfected adult stem cell groups at end reperfusion (n = 5 animals/group).
