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. 2008 Oct 10;295(6):H2242–H2249. doi: 10.1152/ajpheart.00587.2008

Fig. 3.

Fig. 3.

Isolated mice coronary arterioles from CTL mice (without I/R) dilated in a concentration-dependent manner to ACh (n = 10). A: neutralizing antibodies to TNF-α (1.6 mg/per mouse iv, before reperfusion) partially restored ACh-induced coronary arteriolar dilation in murine I/R, but anti-TNF-α did not affect ACh-induced coronary arteriolar dilation in murine sham (n = 4). B: administration of xanthine oxidase inhibitor allopurinol or NAD(P)H oxidase inhibitor apocynin before reperfusion partially maintained vasodilation to ACh in I/R. Furthermore, allopurinol or apocynin did not affect ACh-induced vasodilation in sham groups. However, the combination of allopurinol and apocynin (apocyn) had a greater protective effect than that seen with either agent alone. C: interestingly, I/R mice rendered neutropenic or neutrophil NAD(P)H oxidase inhibitor MFH244 did not affect ACh-induced vasodilation in I/R groups. Values are means ± SD; n = 7. *P < 0.05 vs. sham mice; #P < 0.05 vs. I/R.