Table 2.
n |
Baseline |
10 min of Reperfusion
|
20 min of Reperfusion
|
30 min of Reperfusion
|
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LVSP | LVEDP | LVDP | +dP/dt | −dP/dt | LVSP | LVEDP | LVSP | LVEDP | LVSP | LVEDP | LVDP | %Recovery of LVDP | %Recovery of +dP/dt | %Recovery of −dP/dt | ||
AL | ||||||||||||||||
Without IPC | 6 | 106±5 | 10.2±0.3 | 96±5 | 3,440±220 | 1,910±130 | 70±5 | 26.6±2.5 | 74±5 | 23.9±2.7 | 68±4 | 20.8±2.5 | 47±3 | 49±4 | 54±4 | 57±4 |
With IPC | 4 | 105±5 | 10.1±0.3 | 95±5 | 3,420±280 | 1,890±150 | 70±5 | 28.5±2.7 | 70±5 | 25.8±2.8 | 67±4 | 23.3±2.7 | 44±4 | 46±5 | 51±5 | 55±5 |
CR | ||||||||||||||||
Without IPC | 6 | 106±5 | 10.2±0.3 | 96±5 | 3,410±210 | 1,850±120 | 80±5 | 21.5±2.1 | 84±4* | 14.9±2.0* | 84±4* | 11.3±1.4* | 73±4* | 76±5* | 87±4* | 82±4* |
With IPC | 4 | 105±3 | 10.4±0.1 | 95±3 | 3,390±270 | 1,880±160 | 88±4 | 15.4±1.8 | 91±3* | 13.1±1.8* | 90±2* | 10.9±1.5* | 79±2* | 83±6* | 91±4* | 86±4* |
With l-NAME | ||||||||||||||||
AL | 4 | 107±3 | 10.0±0.1 | 97±3 | 3,410±280 | 1,850±150 | 71±5 | 29.8±2.5 | 70±4 | 23.9±2.3 | 66±4 | 21.5±2.5 | 44±3 | 47±5 | 51±4 | 54±5 |
CR | 4 | 105±3 | 10.1±0.1 | 95±3 | 3,380±270 | 1,870±140 | 74±5 | 25.2±2.3 | 74±4† | 20.1±2.4 | 71±4† | 18.6±2.4† | 52±6† | 54±4† | 60±4† | 61±4† |
Values are means ± SE; n = no. of animals/group. LVSP, left ventricular (LV) systolic pressure (in mmHg); LVEDP, LV end-diastolic pressure (in mmHg); LVDP, LV developed pressure (in mmHg); +dP/dt, peak positive LV dP/dt (in mmHg/s); −dP/dt, peak negative LV dP/dt (in mmHg/s).
P < 0.05 vs. the AL group;
P < 0.05 vs. the corresponding CR group.