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Analysis of the maximal response induced by pinacidil in wild-type (WT), connexin40 (Cx40) knockout (Cx40−/−), and connexin37 (Cx37) knockout (Cx37−/−) mice. A short segment of the arteriole was stimulated with a pulse of the KATP opener pinacidil ejected by pressure from a micropipette. The maximal vasodilator response induced by pinacidil was evaluated at the stimulation pipette site (local) and at locations 500, 1,000, and 2,000 μm upstream.
