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Effects of ANG II (0.1 and 0.01 μM) on basal (A) and NS-induced (B) NPY overflow from mesenteric arterial beds of 4- to 6-wk-old, 10- to 12-wk-old, and 18- to 20-wk-old SHR. Data are plotted as NPY overflow (in ng/ml). Each bar represents mean ± SE of 5–7 preparations. *P < 0.05 and **P < 0.01 compared with the same age control SHRs; ††P < 0.01 compared with 4- to 6-wk-old SHRs; #P < 0.05 compared with 4- to 6-wk-old and 10- to 12-wk-old control SHRs (pre-ANG II).
