Table 3.

Effect of ANG II on NS-induced increases in perfusion pressure (increase from basal in mmHg) from mesenteric bed preparations of WKY rats and SHRs at 4–6, 10–12, and 18–20 wk of age

	WKY Rats	SHRs
0 μM ANG II
4–6 wk old	59±5.8	112±9*
10–12 wk old	68±9.6	154±7*
18–20 wk old	61±11	178±7*
0.01 μM ANG II
4–6 wk old	66±15	156±16*†
10–12 wk old	60±12	190±7*†
18–20 wk old	74±14	175±24*
0.1 μM ANG II
4–6 wk old	60±10	169±10*†
10–12 wk old	76±11	203±12*†
18–20 wk old	44±7	251±9.8*‡

Results are expressed as means ± SE of increases of perfusion pressure from basal (in mmHg); n = 5-7 preparations.

^*P < 0.001 compared to WKY rats;

^†P < 0.05 compared with SHR of the same age with no ANG II;

^‡P < .05, 0.1 μM ANG II compared with 0.01 μM ANG II in 18- to 20-wk-old SHR.