Fig. 1.

Representative Western blot bands showing protein expression of NGF1A-binding protein-1 (Nab1), early growth response-1 transcription factor (Egr1), Na⁺/Ca²⁺ exchanger (NCX), sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA)2a, GATA-4, and β-actin in left ventricular myocardium of 2 normal dogs (NL), 2 placebo dogs (PL), 2 dogs after 3 mo of therapy with ranolazine (Ran), and 2 dogs treated with Ran in combination with enalapril (Ena; Ran + Ena) or Ran in combination with metoprolol (Met; Ran + Met).