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EDHF-dependent vasodilation (ACh-induced vasodilation in the presence of l-NAME and Indo) is 50% of total ACh-induced, endothelium-dependent vasodilation in WT (A, n = 10), whereas it is 81% in db/db mice (B, n = 10). The percentage shown is calculated at the highest dose of ACh (10 μmol/l). NO, nitric oxide; PGI2, prostacyclin. *P < 0.05 vs. WT.
