Fig. 3.

A: incubation of coronary arterioles isolated from WT mice with K⁺ channel blockade [administration of the combination of a nonselective blocker of intermediate-conductance Ca²⁺-activated K⁺ channels (IK_Ca) charybdotoxin (CTX) and a selective blocker of small-conductance Ca²⁺-activated K⁺ channels (SK_Ca) apamin (Apa)], epoxyeicosatrienoic acids blocker, 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE), or catalase reduced EDHF-induced vasodilation. *P < 0.05 vs. WT; n = 7. B: incubation of coronary arterioles isolated from db/db mice with K⁺ channel blockade [administration of the combination of a nonselective blocker of IK_Ca CTX and a selective blocker of SK_Ca Apa] or catalase attenuated EDHF-induced vasodilation; however, incubation of coronary arterioles isolated from db/db mice with 14,15-EEZE did not change EDHF-induced vasodilation. #P < 0.05 vs. db/db (n = 7).