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Schematic of the isolated, perfused mouse heart protocol. Isolated hearts were subjected to either an 80-min perfusion (sham) or an ischemia-reperfusion (I/R) protocol. ATL146e or vehicle infusion was initiated in I/R hearts at the onset of reperfusion. Numbers indicate time points for coronary perfusate (CP) sample collection. B, baseline (preischemia) collection period.
