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ISs in vehicle- and ATL146e-treated A2AAR+/+ and A2AAR−/− BMC mice. ATL146e reduced ISs in irradiated WT mice where A2AAR+/+ bone marrow had been transplanted (WT/WT vehicle and ATL146e) but not in WT irradiated mice where A2AAR−/− bone marrow was transplanted (KO/WT vehicle and ATL146e). n = 7 vehicle-treated KO/WT mice, 7 ATL146e-treated KO/WT mice, 7 vehicle-treated WT/WT mice, and 7 ATL146e-treated WT/WT mice. *P < 0.05 by one-way ANOVA.
