. 2008 Aug 29;295(5):H1825–H1833. doi: 10.1152/ajpheart.495.2008

Table 1.

Receptor binding affinities as determined by radioligand binding for ATL146e and CGS-21680 in the human and mouse A₁AR, A_2AAR, A₃AR, and A_2BAR

	Human A₁AR	Human A_2AAR		Human A₃AR	Human A_2BAR	Mouse A₁AR	Mouse A_2AAR		Mouse A₃AR	Mouse A_2BAR
Low-Affinity Binding Site	Human A₁AR	High-Affinity Binding Site	Low-Affinity Binding Site	Human A₃AR	Human A_2BAR	Mouse A₁AR	High-Affinity Binding Site		Mouse A₃AR	Mouse A_2BAR
ATL146e	23.4±2.2	24.5±6.3	0.68±0.1	6.9±1	>1 μmol/l	65.2±11	6.6±0.68	1.08±0.5	8.87±2.5	3,870±337
CGS-21680	197±27.3	650±67.3	17.3±5.1	27.6±4.7	>1 μmol/l	215±15.3	1,450±301	0.95±0.4	51.1±3	NA

Values are means ± SE of receptor binding affinity (K_i) values (in nmol/l unless otherwise noted). AR, adenosine receptor; NA, not available at the time of publication.