Figure 4.

Cyp2j5 (−/−) female mice have increased afferent arteriolar responses to angiotensin II and endothelin I. Afferent arteriolar responses to increasing doses of angiotensin II (0.01–10 nM) and endothelin I (1–10 nM) in Cyp2j5 (−/−) mice (solid symbols) and Cyp2j5 (+/+) littermate controls (open symbols) are shown for females (A) and males (B). Results are reported as percentage of control diameter; values are means ± se, n = 8–11 mice/group. *P < 0.05 vs. vehicle, #P < 0.05 vs. Cyp2j5 (+/+) mice.